STRUCTURAL PATHWAYS: COMPREHENSIVE MECHANISTIC MOVIE
Spliceosome machinery and pre-mRNA splicing cycle
Presented at:
"Forty Years of mRNA Splicing: From Discovery to Therapeutics"
Cold Spring Harbor Laboratory Symposium (New York)

Movie created for: Prof. Yigong Shi, Ph.D.
Director of Innovation Center for Structural Biology
President, Co-founder, Westlake University & Institute for Advanced Study
Full narrated movie feature 16 min 45 sec
Molecular Mechanisms of Splicing:
Spliceosome Machinery and Pre-Messenger RNA Splicing Cycle
Musical montage 2 min 01 sec
Featured by:
YOUTUBE STREAM
STRUCTURAL MECHANISTIC BREAKTHROUGH
Transporter: enigma of bioenergetic membrane biogenesis solved
Journal cover created for: Schara Safarian, Ph.D.
Max Planck, Institute of Biophysics
Wu et al. Dissecting the conformational complexity and mechanism of a bacterial heme transporter.
Nature Chemical Biology, 2023
MECHANISM, NON-LINEAR TRANSITIONS: MOVIE
Membrane-tethered protein synthesis in human mitochondria
Narrated movie 2 min 20 sec
Movie created for: Prof. Alexey Amunts, Ph.D.
Stockholm University & Karolinska Institutet
Traversal of tunnel milieu probed by simulation. "Birth of a mitochondrial membrane protein"
Itoh et al. Mechanism of membrane-tethered mitochondrial protein synthesis.
Science, 2021
ATOMISTIC MODEL, CONCEPTUALIZATION COLLAB
Microtubule cytoskeleton & traffic: general MAP code

Presented at:
"Microtubules: From Atoms to Complex Systems"
EMBL|EMBO Symposium (Heidelberg, Germany)

Molecular model created for: Prof. Kassandra Ori-McKenney, Ph.D.
University of California, Davis
TESTIMONIAL
"The molecular models from N Molecular Systems are
extremely useful in generating new ideas,
presenting results and ideas in talks and posters,
and providing visualizations for future publications."


PROF. RICHARD J. MCKENNEY, PH.D.
Dept. of Molecular and Cellular Biology
University of California, Davis


FLASHBACK
DCX MAP: 3D domain swapping pathways

Microtubule Associated Protein (MAP) – Doublecortin (DCX)
MODEL SYSTEM CONSTRUCT
Bacterial flagellar system and rotary nanomotor machinery
Created for: Prof. Nicholas M.I. Taylor, Ph.D.
University of Copenhagen, Danmark
Structure and Function of Stator Units of the Bacterial Flagellar Motor.
Cell, 2020
TESTIMONIAL
"The level of detail is truly astounding.
I spent multiple minutes looking at each area, and there is always
new, carefully thought about, info appearing ... a masterpiece!"


PROF. NIKOS HATZAKIS, PH.D.
Single Molecule Laboratory
Novo Nordisk Foundation, Nano-Science Center
University of Copenhagen


RECENT MODEL SYSTEMS
Chromatin remodeling machinery

CHROMATIN LANDSCAPE & DYNAMICS
Conserved architecture and unifying mechanism
High-resolution insights into chromatin remodeler families
(W)HITHER GHOST IN THE MACHINE?
DNA synapse: NHEJ/DNA-repair
Created for: Prof. Yuan He, Ph.D.
Northwestern University
Structural basis for long-range to short-range synaptic transition in NHEJ.
Nature, 2021
STRUCTURAL MECHANISTIC BREAKTHROUGH
Mitoribosome: synthesis of bioenergetic membrane proteins
Journal cover created for: Prof. Alexey Amunts, Ph.D.
Stockholm University & Karolinska Institutet
Itoh et al. Mechanism of membrane-tethered mitochondrial protein synthesis.
Science, 2021
MOLECULAR VISUALIZATION OF MACHINE LEARNING IMPLEMENTATION
Decoding pathways via liposome fusion, DNA-guided nanoreactors
Machine learning decoding of >500 reaction sequences from 16,000 real-time TIRF observations. Click for detail.
Created for: Prof. Nikos Hatzakis, Ph.D.
University of Copenhagen
Malle et al. Single-particle combinatorial multiplexed liposome fusion mediated by DNA.
Nature Chemistry, 2022
TESTIMONIAL
"The blend between scientific detail and artistic depth
is what makes the work so unique."


SCHARA SAFARIAN, PH.D.
Head of Research
Biotherapeutic Drug Development & Protein Engineering
Fraunhofer ITMP

Project Group Leader
Max Planck, Institute of Biophysics


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